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View Diary: A little scared tonight.... (76 comments)

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  •  A maintenance dose and a therapeutic dose (0+ / 0-)

    are totally different beasts.  Addisonian dogs are often started out with a cross between the two, and it's like pulling teeth to get the vets to back down on the pred, even when it's obvious (to the owner) the dog is getting too much (peeing and eating machines).  My spoo weighed a little over 50 pounds and the .75 mg was perfect - for him.

    I find too many people are so fearful of pred they don't see it for the miracle drug it is - sometimes it's the only thing that works; other times it's the simplest solution to an otherwise life-threatening condition.

    I see 11-beta hydroxylase deficiency is autosomal recessive - any knowledge of other affecteds in your family? At one time Addisons was thought to be autosomal recessive in standard poodles but not anymore.  It's still thought to be highly heritable but the mechanism is not known.  Sad - it's a big problem in the breed - diagnosis is usually only during a crisis ($$$$$), too many dogs are misdiagnosed (kidney failure), and it ain't cheap to treat (unless you're willing and able to buy the meds at cost and give the injections yourself).

    Out with the gloomage - in with the plumage!

    by mikidee on Wed Jan 30, 2013 at 09:31:22 AM PST

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    •  i don't have access to my family information (0+ / 0-)

      except very sketchily.  there have to be, by virtue of the mutation, others with the active disease, and half of my siblings would be carriers.  One of the most notable family history factors in CAH on the whole is low fertility: mainly due to the influence of excess androgen production.  And that is typical in my family as well.  I would very much like to help out the generation moving forward - I have two nieces, but I have no contact with them. I have conveyed all the information I could, but they have little to no interest in anything i have to say. It is quite sad.

      "Kossacks are held to a higher standard. Like Hebrew National hot dogs." - blueaardvark

      by louisev on Wed Jan 30, 2013 at 11:04:19 AM PST

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