I don't think she'd be able to pull off a run for national office ever again, for one basic reason: YouTube.
Four years from now, assuming that President Obama is at least an average President, people will have learned that no, he's not a Socialist, or Muslim (who, as a people, we have no problem with, right, everybody?), a terrorist, or even a friend to terrorists.
In light of this "new" knowledge, Sarah Palin's remarks, which will undoubtedly be "unearthed," will seem perfectly absurd. We can point out the half-dozen or so rumors she willingly spread.
What's more, we will be armed with proof that she didn't know what the Vice President does, or understand the purpose of the First Amendment.
She is sunk. Thank you, YouTube.