A recent discovery was made regarding Otzi the Iceman. It's that he had heart disease and shows a genetic predisposition for heart disease. Very interesting, and worthy of study. However in the Huffpo write up of this story, the following comment was made:
Despite spending years hiking in hilly terrain, it seems Ötzi couldn't walk off his genetic predisposition to heart disease.
"He didn't smoke; he was very active; he walked a lot; he was not obese," Zink said. "But nevertheless, he already developed some atherosclerosis."
I would dispute that. Otzi did smoke. He spent all his life around open wood burning fires to keep warm, to cook food, and to provide light. And that means airborne particulate matter that would have impacted his genetic issues regarding heart disease.