Potential COVID-19 Treatments
"Companies around the world are developing treatments for COVID-19. This list will be updated as new developments become public."www.nbcnews.com/...
Vaccine Candidates
- MRNA-1273 by Moderna
- Trial Status: Phase I human testing
- REGM3048-3051 by Regeneron
- Trial Status: Preclinical testing, human testing goal for early summer
- INO-4800 by Inovio Pharmaceuticals
- Trial Status: Preclinical testing, human testing goal for April
- Unnamed Vaccine by Johnson & Johnson/Janssen Pharmaceutical Company
- Effect on Covid-19: Vaccine (preventative)
- Trial Status: Preclinical testing with aim to identify vaccine by end of March, begin clinical trials in November
- Unnamed Vaccine by Pfizer/Biontech
- Trial Status: Clinical testing by end of April
- Unnamed Vaccine by Sanofi
- Trial Status: Ongoing at lab in Meridien, Connecticut. Estimate in vitro testing within six months and potentially clinical trials in 1 year to 18 months
- Unnamed Vaccine by Novavax/Emergent Biosolutions
- Trial Status: Studying in animals and human trials expected to begin late spring.
Potential Treatments
- PICLIDENOSON by Can-Fite
- Recommended Use: Anti-Viral
- Effect on Covid-19: Prophylactic and a treatment
- Trial Status: Gone through phase I And II Of clinical trials for rheumatoid arthritis
- EIDD-2801 by Drug Innovation Ventures at Emory
- Recommended Use: SARS, MERS, Ebola, Influenza
- Effect on Covid-19: Oral treatment taken at onset
- Trial Status: Preclinical testing
Repurposed Treatments
- ACTEMRA by Roche
- Recommended Use: Rheumatoid arthritis
- Effect on Covid-19: For severe lung inflammation
- Trial Status: FDA approved for rheumatoid arthritis, clinical trials for COVID
- KEVZARA (sarilumab) by Regeneron and Sanofi
- Recommended Use: Rheumatoid arthritis
- Effect on Covid-19: For severe lung inflammation
- Trial Status: Will begin enrolling immediately
- HYDROXYCHLOROQUINE by Sanofi
- Recommended Use: Malaria, Lupus
- Trial Status: Tested in France and investigating use in U.S.
- REMDESIVIR by Gilead Sciences
- Recommended Use: Ebola
- Trial Status: Clinical trials at 50 sites globally with goal of 394 patients
- KALETRA/ALUVIA by AbbVie
- Recommended Use: HIV
- Trial Status: Clinical trial in China among 20 individuals showed no improvement, clinical trial with 2400 patients to begin in Australia
- OLUMIANT by Eli Lilly
- Recommended Use: Rheumatoid arthritis
- Trial Status: Laboratory research to evaluate the benefits and risks
- FAVIRPIRAVIR by Fujifilm Toyama Chemical
- Recommended Use: Influenza
- Effect on Covid-19: Normilization of fever in patients in early diagnosis (4 days or less)
- Trial Status: Being tested in patients in China and it has been effective in those without severe symptoms
Hydroxychloroquine, a medicine for malaria that President Donald Trump has touted as a treatment for coronavirus, was no more effective than conventional care, a small study found.
The report published by the Journal of Zhejiang University in China showed that patients who got the medicine didn’t fight off the new coronavirus more often than those who did not get the medicine.
"chloroquine/hydroxychloroquine has shown promise in the lab for many viral infections, the drug shows no benefit when tested on an animal. “Chloroquine has been proposed several times for the treatment of acute viral diseases in humans without success,” the authors argue."
www.bloomberg.com/...
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Thursday, Mar 26, 2020 · 2:53:32 AM +00:00 · Angmar
California based Cepheid got approval for a 45-minute test, they plan to start rolling it out by March 30.
The diagnostic test for the virus that causes COVID-19 has been designed to operate on any of Cepheid’s more than 23,000 automated GeneXpert Systems globally, the company said.
The systems do not require users to have special training to perform testing, and are capable of running around the clock, Cepheid President Warren Kocmond said in the statement.